Tulokset ja otteluohjelma
 | | PVM | Vastustaja | Tulokset | Maalintekijät | Yleisöä |
| 12.08.2007 | Reading (K) | 0 - 0 |  | - | 75,655 |
| 15.08.2007 | Portsmouth (V) | 1 - 1 | | Scholes (15) | 20,510 |
| 19.08.2007 | Manchester City (V) | 1 - 0 |  | - | 44,955 |
| 26.08.2007 | Tottenham (K) | 1 - 0 |  | Nani (68) | 75,696 |
| 01.09.2007 | Sunderland (K) | 1 - 0 | | Saha (72) | 75,648 |
| 15.09.2007 | Everton (V) | 0 - 1 | | Vidic (83) | 39,364 |
| 23.09.2007 | Chelsea (K) | 2 - 0 | | Tevez (45) Saha (90, rp) | 75,663 |
| 29.09.2007 | Birmingham City (V) | 0 - 1 | | Ronaldo (51) | 26,526 |
| 06.10.2007 | Wigan Athletic (K) | 4 - 0 | | Tevez (54) Ronaldo (59; 76) Rooney (82) | 75,300 |
| 20.10.2007 | Aston Villa (V) | 1 - 4 | | Rooney (36; 44) Ferdinand (45) Giggs (75) | 42,640 |
| 27.10.2007 | Middlesbrough (K) | 4 - 1 | | Nani (3) Rooney (33) Tevez (55; 85) | 75,720 |
| 03.11.2007 | Arsenal (V) | 2 - 2 | | Gallas (45, om) Ronaldo (82) | 60,161 |
| 11.11.2007 | Blackburn Rovers (K) | 2 - 0 | | Ronaldo (34; 35) | 75,710 |
| 24.11.2007 | Bolton Wanderers (V) | 1 - 0 | | - | 25,028 |
| 03.12.2007 | Fulham (K) | 2 - 0 | | Ronaldo (10; 58) | 75,055 |
| 08.12.2007 | Derby County (K) | 4 - 1 | | Giggs (40) Tevez (45; 60) Ronaldo (90, rp) | 75,725 |
| 16.12.2007 | Liverpool (V) | 0 - 1 | | Tevez (43) | 44,459 |
| 23.12.2007 | Everton (K) | 2 - 1 | | Ronaldo (22; 88, rp) | 75,749 |
| 26.12.2007 | Sunderland (V) | 0 - 4 | | Rooney (20) Saha (30; 86, rp) Ronaldo (45) | 47,360 |
| 29.12.2007 | West Ham (V) | 2 - 1 | | Ronaldo (14) | 34,966 |
| 01.01.2008 | Birmingham City (K) | 1 - 0 | | Tevez (25) | 75,459 |
| 12.01.2008 | Newcastle United (K) | 6 - 0 | | Ronaldo (49; 70; 88) Tevez (55; 90) Ferdinand (85) | 75,965 |
| 19.01.2008 | Reading (V) | 0 - 2 | | Rooney (77) Ronaldo (90) | 24,135 |
| 30.01.2008 | Portsmouth (K) | 2 - 0 | | Ronaldo (10; 13) | 75,415 |
| 02.02.2008 | Tottenham (V) | 1 - 1 | | Tevez (90) | 36,075 |
| 10.02.2008 | Manchester City (K) | 1 - 2 | | Carrick (90) | 75,970 |
| 23.02.2008 | Newcastle United (V) | 1 - 5 | | Rooney (25; 80) Ronaldo (45; 56) Saha (90) | 52,291 |
| 01.03.2008 | Fulham (V) | 0 - 3 | | Hargreaves (15) Park (45) Davies (72, om) | 25,314 |
| 15.03.2008 | Derby County (V) | 0 - 1 | | Ronaldo (76) | 33,072 |
| 19.03.2008 | Bolton Wanderers (K) | 2 - 0 | | Ronaldo (9; 19) | 75,476 |
| 23.03.2008 | Liverpool (K) | 3 - 0 | | Brown (34) Ronaldo (79) Nani (81) | 76,000 |
| 29.03.2008 | Aston Villa (K) | 4 - 0 | | Ronaldo (17) Tevez (33) Rooney (53; 70) | 75,932 |
| 06.04.2008 | Middlesbrough (V) | 2 - 2 | | Ronaldo (10) Rooney (74) | 33,952 |
| 13.04.2008 | Arsenal (K) | 2 - 1 | | Ronaldo (54, rp) Hargreaves (72) | 75,985 |
| 19.04.2008 | Blackburn Rovers (V) | 1 - 1 | | Tevez (88) | 30,316 |
| 26.04.2008 | Chelsea (V) | 2 - 1 | | Rooney (57) | 41,828 |
| 03.05.2008 | West Ham (K) | 4 - 1 | | Ronaldo (3; 24) Tevez (26) Carrick (59) | 76,013 |
| 11.05.2008 | Wigan Athletic (V) | 0 - 2 | | Ronaldo (33, rp) Giggs (80) | 25,133 |
 | | PVM | Vastustaja | Tulokset | Maalintekijät | Yleisöä |
| 05.08.2007 | Chelsea (N) * (0-3 (rp)) | 1 - 1 | | Giggs (35) | 80,731 |
 | | PVM | Vastustaja | Tulokset | Maalintekijät | Yleisöä |
| 05.01.2008 | Aston Villa (V) | 0 - 2 | | Ronaldo (81) Rooney (89) | 33,630 |
| 27.01.2008 | Tottenham (K) | 3 - 1 | | Tevez (38) Ronaldo (69, rp; 88) | 75,369 |
| 16.02.2008 | Arsenal (K) | 4 - 0 | | Rooney (16) Fletcher (20; 74) Nani (38) | 75,550 |
| 08.03.2008 | Portsmouth (K) | 0 - 1 | | - | 75,463 |
 | | PVM | Vastustaja | Tulokset | Maalintekijät | Yleisöä |
| 17.07.2007 | Urawa Red Diamonds (K) | 2 - 2 | | Fletcher (49) Ronaldo (52) | 58,716 |
| 20.07.2007 | FC Seoul (K) | 0 - 4 | | Ronaldo (6) Eagles (19) Rooney (21) Evra (60) | 60,000 |
| 23.07.2007 | Shenzhen FC (K) | 0 - 6 | | Giggs (12) Rooney (20) Nani (23) O´Shea (55) Ronaldo (58) Eagles (62) | 0 |
| 27.07.2007 | Guangzhou Pharmac. (K) | 0 - 3 | | Rooney (20, rp) Nani (44) Martin (50) | 0 |
| 01.08.2007 | Inter (K) | 2 - 3 | | Rooney (18) Adriano (57, om) | 73,738 |
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