Tulokset ja otteluohjelma
 | | PVM | Vastustaja | Tulokset | Maalintekijät | Yleisöä |
| 31.08.2008 | Athletic Bilbao (V) | 1 - 3 |  | Pellerano (8) Negredo (33) Ortiz (50) | 35,000 |
| 14.09.2008 | Valencia (K) | 2 - 2 |  | Piatti (20) Negredo (40) | 10,000 |
| 21.09.2008 | Malaga (K) | 1 - 0 | | Negredo (75) | 0 |
| 25.09.2008 | Real Valladolid (V) | 2 - 0 |  | - | 14,281 |
| 28.09.2008 | Recreativo Huelva (K) | 1 - 0 | | Negredo (90) | 17,600 |
| 05.10.2008 | Getafe (V) | 2 - 2 | | Negredo (88) Chico (90) | 9,000 |
| 19.10.2008 | Sevilla FC (K) | 0 - 1 | | - | 18,000 |
| 25.10.2008 | Barcelona (V) | 5 - 0 | | - | 78,000 |
| 02.11.2008 | Real Madrid (K) | 1 - 1 | | Piatti (82) | 15,000 |
| 09.11.2008 | Villarreal (V) | 2 - 1 | | Piatti (61) | 20,000 |
| 16.11.2008 | Mallorca (K) | 2 - 1 | | Negredo (44; 67, rp) | 15,000 |
| 23.11.2008 | Osasuna (V) | 3 - 1 | | Negredo (7, rp) Pellerano (71, om) | 15,000 |
| 30.11.2008 | Deportivo La Coruna (K) | 0 - 1 | | - | 12,000 |
| 07.12.2008 | Numancia CD (V) | 18:00 |  | - | |
| 14.12.2008 | Racing Santander (K) | 18:00 | | - | |
| 21.12.2008 | Sporting de Gijon (V) | 18:00 | | - | |
| 04.01.2009 | Real Betis (K) | 18:00 | | - | |
| 11.01.2009 | Espanyol (V) | 18:00 | | - | |
| 18.01.2009 | Atletico Madrid (K) | 18:00 | | - | |
| 25.01.2009 | Athletic Bilbao (K) | 18:00 | | - | |
| 01.02.2009 | Valencia (V) | 18:00 | | - | |
| 08.02.2009 | Malaga (V) | 18:00 | | - | |
| 15.02.2009 | Real Valladolid (K) | 18:00 | | - | |
| 22.02.2009 | Recreativo Huelva (V) | 18:00 | | - | |
| 01.03.2009 | Getafe (K) | 18:00 | | - | |
| 08.03.2009 | Sevilla FC (V) | 18:00 | | - | |
| 15.03.2009 | Barcelona (K) | 18:00 | | - | |
| 22.03.2009 | Real Madrid (V) | 18:00 | | - | |
| 05.04.2009 | Villarreal (K) | 18:00 | | - | |
| 12.04.2009 | Mallorca (V) | 18:00 | | - | |
| 19.04.2009 | Osasuna (K) | 18:00 | | - | |
| 22.04.2009 | Deportivo La Coruna (V) | 18:00 | | - | |
| 26.04.2009 | Numancia CD (K) | 18:00 | | - | |
| 03.05.2009 | Racing Santander (V) | 18:00 | | - | |
| 10.05.2009 | Sporting de Gijon (K) | 18:00 | | - | |
| 17.05.2009 | Real Betis (V) | 18:00 | | - | |
| 24.05.2009 | Espanyol (K) | 18:00 | | - | |
| 31.05.2009 | Atletico Madrid (V) | 18:00 | | - | |
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