Tulokset ja otteluohjelma
 | | PVM | Vastustaja | Tulokset | Maalintekijät | Yleisöä |
| 31.08.2008 | Malaga (K) | 4 - 0 |  | Heitinga (26) Forlan (38; 43, rp) Sinama-Pongolle (81) | 50,000 |
| 13.09.2008 | Real Valladolid (V) | 2 - 1 |  | Aguero (55) | 20,000 |
| 21.09.2008 | Recreativo Huelva (K) | 4 - 0 | | Aguero (8) Maniche (53) Sinama-Pongolle (78; 89) | 50,000 |
| 24.09.2008 | Getafe (V) | 1 - 2 | | Sinama-Pongolle (30) Cortes (82, om) | 12,000 |
| 28.09.2008 | Sevilla FC (K) | 0 - 1 | | - | 40,000 |
| 04.10.2008 | Barcelona (V) | 6 - 1 | | Rodriguez (13) | 75,232 |
| 18.10.2008 | Real Madrid (K) | 1 - 2 | | Sabrosa (90) | 57,500 |
| 26.10.2008 | Villarreal (V) | 4 - 4 |  | Sabrosa (1; 83) Forlan (22) Garcia (85) | 20,000 |
| 01.11.2008 | Mallorca (K) | 2 - 0 | | Aguero (14; 28) | 42,000 |
| 09.11.2008 | Osasuna (V) | 0 - 0 | | - | 15,000 |
| 16.11.2008 | Deportivo La Coruna (K) | 4 - 1 | | Heitinga (26) Forlan (52; 81) Rodriguez (67) | 0 |
| 23.11.2008 | Numancia CD (V) | 1 - 1 | | Forlan (34) | 10,000 |
| 30.11.2008 | Racing Santander (K) | 4 - 1 | | Sabrosa (21) Aguero (34) Forlan (78; 81) | 30,000 |
| 07.12.2008 | Sporting de Gijon (V) | 18:00 |  | - | |
| 14.12.2008 | Real Betis (K) | 18:00 | | - | |
| 21.12.2008 | Espanyol (V) | 18:00 | | - | |
| 04.01.2009 | Valencia (V) | 18:00 | | - | |
| 11.01.2009 | Athletic Bilbao (K) | 18:00 | | - | |
| 18.01.2009 | Almeria (V) | 18:00 | | - | |
| 25.01.2009 | Malaga (V) | 18:00 | | - | |
| 01.02.2009 | Real Valladolid (K) | 18:00 | | - | |
| 08.02.2009 | Recreativo Huelva (V) | 18:00 | | - | |
| 15.02.2009 | Getafe (K) | 18:00 | | - | |
| 22.02.2009 | Sevilla FC (V) | 18:00 | | - | |
| 01.03.2009 | Barcelona (K) | 18:00 | | - | |
| 08.03.2009 | Real Madrid (V) | 18:00 | | - | |
| 15.03.2009 | Villarreal (K) | 18:00 | | - | |
| 22.03.2009 | Mallorca (V) | 18:00 | | - | |
| 05.04.2009 | Osasuna (K) | 18:00 | | - | |
| 12.04.2009 | Deportivo La Coruna (V) | 18:00 | | - | |
| 19.04.2009 | Numancia CD (K) | 18:00 | | - | |
| 22.04.2009 | Racing Santander (V) | 18:00 | | - | |
| 26.04.2009 | Sporting de Gijon (K) | 18:00 | | - | |
| 03.05.2009 | Real Betis (V) | 18:00 | | - | |
| 10.05.2009 | Espanyol (K) | 18:00 | | - | |
| 17.05.2009 | Valencia (K) | 18:00 | | - | |
| 24.05.2009 | Athletic Bilbao (V) | 18:00 | | - | |
| 31.05.2009 | Almeria (K) | 18:00 | | - | |
 | | PVM | Vastustaja | Tulokset | Maalintekijät | Yleisöä |
| 13.08.2008 | Schalke 04 (V) | 1 - 0 | | - | 54,142 |
| 27.08.2008 | Schalke 04 (K) | 4 - 0 | | Aguero (22) Forlan (54) Garcia (82) Rodriguez (86, rp) | 55,000 |
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