Tulokset ja otteluohjelma
 | | PVM | Vastustaja | Tulokset | Maalintekijät | Yleisöä |
| 31.08.2008 | Deportivo La Coruna (V) | 2 - 1 |  | van Nistelrooy (47) | 32,000 |
| 14.09.2008 | Numancia CD (K) | 4 - 3 |  | Guti (19) Higuain (26) van der Vaart (33) Cisma (40, om; 40, om) | 80,000 |
| 21.09.2008 | Racing Santander (V) | 0 - 2 | | de la Red (54) van Nistelrooy (74) | 20,000 |
| 24.09.2008 | Sporting de Gijon (K) | 6 - 1 | | van der Vaart (18; 33; 47) Higuain (37) Robben (51) Raul (59; 64) | 70,000 |
| 28.09.2008 | Real Betis (V) | 1 - 2 | | Heinze (19) van Nistelrooy (90) | 49,000 |
| 05.10.2008 | Espanyol (K) | 2 - 2 |  | Raul (25; 45) | 65,000 |
| 18.10.2008 | Atletico Madrid (V) | 1 - 2 | | van Nistelrooy (1) Higuain (90, rp) | 57,500 |
| 26.10.2008 | Athletic Bilbao (K) | 3 - 2 | | Sneijder (13) Higuain (29; 59) | 80,000 |
| 02.11.2008 | Almeria (V) | 1 - 1 | | Raul (38) | 15,000 |
| 08.11.2008 | Malaga (K) | 4 - 3 | | Higuain (8; 37, rp; 71; 78) | 70,000 |
| 16.11.2008 | Real Valladolid (V) | 1 - 0 | | - | 21,097 |
| 23.11.2008 | Recreativo Huelva (K) | 18:00 |  | - | |
| 30.11.2008 | Getafe (V) | 18:00 | | - | |
| 07.12.2008 | Sevilla FC (K) | 18:00 | | - | |
| 14.12.2008 | Barcelona (V) | 18:00 | | - | |
| 21.12.2008 | Valencia (K) | 18:00 | | - | |
| 04.01.2009 | Villarreal (K) | 18:00 | | - | |
| 11.01.2009 | Mallorca (V) | 18:00 | | - | |
| 18.01.2009 | Osasuna (K) | 18:00 | | - | |
| 25.01.2009 | Deportivo La Coruna (K) | 18:00 | | - | |
| 01.02.2009 | Numancia CD (V) | 18:00 | | - | |
| 08.02.2009 | Racing Santander (K) | 18:00 | | - | |
| 15.02.2009 | Sporting de Gijon (V) | 18:00 | | - | |
| 22.02.2009 | Real Betis (K) | 18:00 | | - | |
| 01.03.2009 | Espanyol (V) | 18:00 | | - | |
| 08.03.2009 | Atletico Madrid (K) | 18:00 | | - | |
| 15.03.2009 | Athletic Bilbao (V) | 18:00 | | - | |
| 22.03.2009 | Almeria (K) | 18:00 | | - | |
| 05.04.2009 | Malaga (V) | 18:00 | | - | |
| 12.04.2009 | Real Valladolid (K) | 18:00 | | - | |
| 19.04.2009 | Recreativo Huelva (V) | 18:00 | | - | |
| 22.04.2009 | Getafe (K) | 18:00 | | - | |
| 26.04.2009 | Sevilla FC (V) | 18:00 | | - | |
| 03.05.2009 | Barcelona (K) | 18:00 | | - | |
| 10.05.2009 | Valencia (V) | 18:00 | | - | |
| 17.05.2009 | Villarreal (V) | 18:00 | | - | |
| 24.05.2009 | Mallorca (K) | 18:00 | | - | |
| 31.05.2009 | Osasuna (V) | 18:00 | | - | |
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