Tulokset ja otteluohjelma
 | | PVM | Vastustaja | Tulokset | Maalintekijät | Yleisöä |
| 31.08.2008 | Catania (V) | 1 - 0 |  | - | 22,000 |
| 14.09.2008 | AC Milan (K) | 2 - 0 |  | Sculli (30) Milito (90) | 30,000 |
| 21.09.2008 | Palermo (V) | 2 - 0 | | Bovo (58) | 20,101 |
| 24.09.2008 | AS Roma (K) | 3 - 1 | | Sculli (4) Milito (61; 87) | 25,000 |
| 28.09.2008 | Fiorentina (V) | 1 - 0 | | - | 30,000 |
| 05.10.2008 | Napoli (K) | 3 - 2 | | Papastrathopoulos (44) Palladino (52) Milito (73) | 25,000 |
| 19.10.2008 | Siena (K) | 1 - 0 | | Biava (20) | 24,571 |
| 26.10.2008 | Inter (V) | 0 - 0 |  | - | 50,000 |
| 29.10.2008 | Cagliari (K) | 2 - 1 | | Papastrathopoulos (24) Motta (55) | 24,000 |
| 02.11.2008 | Udinese (V) | 2 - 2 | | Milito (63, rp) Sculli (67) | 14,000 |
| 09.11.2008 | Reggina (K) | 4 - 0 | | Milito (54, rp; 74; 90) Sculli (81) | 25,000 |
| 13.11.2008 | Juventus (V) | 4 - 1 | | Milito (88) Papastrathopoulos (92, om) | 24,463 |
| 23.11.2008 | Lazio (V) | 16:00 |  | - | |
| 30.11.2008 | Bologna (K) | 16:00 | | - | |
| 07.12.2008 | Sampdoria (V) | 16:00 | | - | |
| 14.12.2008 | Atalanta (K) | 16:00 | | - | |
| 21.12.2008 | Chievo (V) | 16:00 | | - | |
| 11.01.2009 | Torino (K) | 16:00 | | - | |
| 18.01.2009 | Lecce (V) | 16:00 | | - | |
| 25.01.2009 | Catania (K) | 16:00 | | - | |
| 28.01.2009 | AC Milan (V) | 16:00 | | - | |
| 01.02.2009 | Palermo (K) | 16:00 | | - | |
| 08.02.2009 | AS Roma (V) | 16:00 | | - | |
| 15.02.2009 | Fiorentina (K) | 16:00 | | - | |
| 22.02.2009 | Napoli (V) | 16:00 | | - | |
| 01.03.2009 | Siena (V) | 16:00 | | - | |
| 08.03.2009 | Inter (K) | 16:00 | | - | |
| 15.03.2009 | Cagliari (V) | 16:00 | | - | |
| 22.03.2009 | Udinese (K) | 16:00 | | - | |
| 05.04.2009 | Reggina (V) | 16:00 | | - | |
| 11.04.2009 | Juventus (K) | 16:00 | | - | |
| 19.04.2009 | Lazio (K) | 16:00 | | - | |
| 26.04.2009 | Bologna (V) | 16:00 | | - | |
| 03.05.2009 | Sampdoria (K) | 16:00 | | - | |
| 10.05.2009 | Atalanta (V) | 16:00 | | - | |
| 17.05.2009 | Chievo (K) | 16:00 | | - | |
| 24.05.2009 | Torino (V) | 16:00 | | - | |
| 31.05.2009 | Lecce (K) | 16:00 | | - | |
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