Tulokset ja otteluohjelma
 | | PVM | Vastustaja | Tulokset | Maalintekijät | Yleisöä |
| 30.08.2008 | Sampdoria (V) | 1 - 1 |  | Ibrahimovic (33) | 34,000 |
| 14.09.2008 | Catania (K) | 2 - 1 |  | Quaresma (43) Terlizzi (48, om) | 0 |
| 21.09.2008 | Torino (V) | 1 - 3 | | Pisano (24, om) Maicon (26) Ibrahimovic (51) | 23,000 |
| 24.09.2008 | Lecce (K) | 1 - 0 | | Cruz (79) | 45,000 |
| 28.09.2008 | AC Milan (V) | 1 - 0 |  | - | 79,057 |
| 05.10.2008 | Bologna (K) | 2 - 1 | | Ibrahimovic (24) Adriano (49) | 47,913 |
| 19.10.2008 | AS Roma (V) | 0 - 4 | | Ibrahimovic (6; 47) Stankovic (53) Obinna (55) | 48,000 |
| 26.10.2008 | Genoa (K) | 0 - 0 | | - | 50,000 |
| 29.10.2008 | Fiorentina (V) | 0 - 0 | | - | 36,358 |
| 01.11.2008 | Reggina (V) | 2 - 3 | | Maicon (9) Vieira (23) Cordoba (90) | 18,000 |
| 09.11.2008 | Udinese (K) | 1 - 0 | | Cruz (90) | 50,000 |
| 15.11.2008 | Palermo (V) | 0 - 2 | | Ibrahimovic (47; 61) | 34,203 |
| 23.11.2008 | Juventus (K) | 16:00 |  | - | |
| 30.11.2008 | Napoli (K) | 16:00 | | - | |
| 07.12.2008 | Lazio (V) | 16:00 | | - | |
| 14.12.2008 | Chievo (K) | 16:00 | | - | |
| 21.12.2008 | Siena (V) | 16:00 | | - | |
| 11.01.2009 | Cagliari (K) | 16:00 | | - | |
| 18.01.2009 | Atalanta (V) | 16:00 | | - | |
| 25.01.2009 | Sampdoria (K) | 16:00 | | - | |
| 28.01.2009 | Catania (V) | 16:00 | | - | |
| 01.02.2009 | Torino (K) | 16:00 | | - | |
| 08.02.2009 | Lecce (V) | 16:00 | | - | |
| 15.02.2009 | AC Milan (K) | 16:00 | | - | |
| 22.02.2009 | Bologna (V) | 16:00 | | - | |
| 01.03.2009 | AS Roma (K) | 16:00 | | - | |
| 08.03.2009 | Genoa (V) | 16:00 | | - | |
| 15.03.2009 | Fiorentina (K) | 16:00 | | - | |
| 22.03.2009 | Reggina (K) | 16:00 | | - | |
| 05.04.2009 | Udinese (V) | 16:00 | | - | |
| 11.04.2009 | Palermo (K) | 16:00 | | - | |
| 19.04.2009 | Juventus (V) | 16:00 | | - | |
| 26.04.2009 | Napoli (V) | 16:00 | | - | |
| 03.05.2009 | Lazio (K) | 16:00 | | - | |
| 10.05.2009 | Chievo (V) | 16:00 | | - | |
| 17.05.2009 | Siena (K) | 16:00 | | - | |
| 24.05.2009 | Cagliari (V) | 16:00 | | - | |
| 31.05.2009 | Atalanta (K) | 16:00 | | - | |
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