Tulokset ja otteluohjelma
 | | PVM | Vastustaja | Tulokset | Maalintekijät | Yleisöä |
| 30.08.2008 | Udinese (V) | 3 - 1 |  | Bresciano (69) | 30,000 |
| 14.09.2008 | AS Roma (K) | 3 - 1 |  | Miccoli (19; 56) Cavani (72) | 22,557 |
| 21.09.2008 | Genoa (K) | 2 - 0 | | Cavani (38) Bovo (58) | 20,101 |
| 24.09.2008 | Napoli (V) | 2 - 1 | | Miccoli (83) | 30,000 |
| 28.09.2008 | Reggina (K) | 1 - 0 | | Miccoli (51) | 19,235 |
| 05.10.2008 | Juventus (V) | 1 - 2 | | Miccoli (23) Mchedlidze (80) | 22,495 |
| 19.10.2008 | Catania (V) | 2 - 0 | | - | 19,061 |
| 26.10.2008 | Fiorentina (K) | 1 - 3 | | Simplicio (50) | 21,679 |
| 29.10.2008 | Lecce (V) | 1 - 1 |  | Cavani (88) | 9,437 |
| 02.11.2008 | Chievo (K) | 3 - 0 | | Miccoli (23) Kjaer (37) Cavani (45) | 19,076 |
| 08.11.2008 | Torino (V) | 1 - 0 | | - | 15,000 |
| 15.11.2008 | Inter (K) | 0 - 2 | | - | 34,203 |
| 23.11.2008 | Bologna (V) | 1 - 1 | | Succi (92) | 17,837 |
| 30.11.2008 | AC Milan (K) | 3 - 1 | | Miccoli (50) Cavani (59) Simplicio (80) | 33,998 |
| 07.12.2008 | Cagliari (V) | 16:00 |  | - | |
| 14.12.2008 | Siena (K) | 16:00 | | - | |
| 21.12.2008 | Lazio (V) | 16:00 | | - | |
| 11.01.2009 | Atalanta (K) | 16:00 | | - | |
| 18.01.2009 | Sampdoria (V) | 16:00 | | - | |
| 25.01.2009 | Udinese (K) | 16:00 | | - | |
| 28.01.2009 | AS Roma (V) | 16:00 | | - | |
| 01.02.2009 | Genoa (V) | 16:00 | | - | |
| 08.02.2009 | Napoli (K) | 16:00 | | - | |
| 15.02.2009 | Reggina (V) | 16:00 | | - | |
| 22.02.2009 | Juventus (K) | 16:00 | | - | |
| 01.03.2009 | Catania (K) | 16:00 | | - | |
| 08.03.2009 | Fiorentina (V) | 16:00 | | - | |
| 15.03.2009 | Lecce (K) | 16:00 | | - | |
| 22.03.2009 | Chievo (V) | 16:00 | | - | |
| 05.04.2009 | Torino (K) | 16:00 | | - | |
| 11.04.2009 | Inter (V) | 16:00 | | - | |
| 19.04.2009 | Bologna (K) | 16:00 | | - | |
| 26.04.2009 | AC Milan (V) | 16:00 | | - | |
| 03.05.2009 | Cagliari (K) | 16:00 | | - | |
| 10.05.2009 | Siena (V) | 16:00 | | - | |
| 17.05.2009 | Lazio (K) | 16:00 | | - | |
| 24.05.2009 | Atalanta (V) | 16:00 | | - | |
| 31.05.2009 | Sampdoria (K) | 16:00 | | - | |
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